The Delgoffe Lab is coming to SITC 2019!

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And we are presenting! Come check out our work on Nov. 6–10, 2019 at the Gaylord National Hotel & Convention Center in National Harbor, MD.

Greg Delgoffe: Regulation of Cancer Immunity by Metabolic and Microbiome Interactions (Primer Session 2: Tumor Immunity II; Thurs @10:10am)

Kristin DePeaux: Therapeutic efficacy of oncolytic vaccinia virus requires infection and removal of deleterious host immune cells (P648)

Ashley Menk: Tumor cell metabolism as a barrier to immunotherapy in melanoma (P745)

Nicole Scharping: Chronic activation under hypoxia drives T cell differentiation to exhaustion (Concurrent Session 205: Biology of T cells; Fri @6:05pm)

Paolo Vignali: CD8+ T cells potentiate the tolerogenic tumor microenvironment as functional suppressors (P568)

Mac Watson: Tumor-infiltrating regulatory T cell function is metabolically supported through lactate-mediated symbiosis with the tumor microenvironment (Rapid Oral Presentation; Sat @1:36pm)

Delgoffe Lab @ SITC 2018!

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The Delgoffe lab is ready for the Society for Immunotherapy of Cancer (SITC) 33rd Annual Meeting in Washington D.C.! The whole gang will be there, and we are presenting!

Four lab members are giving talks at SITC 2018!

  • Nicole Scharping on Friday @ 1:30pm - Chronic T cell activation and metabolic stress promote the exhausted T cell state by inducing epigenetic inflexibility (also poster P207)

  • Greg M. Delgoffe on Friday @ 5:25pm - Enhancement of Oncolytic Virus Immunotherapy Through Vector-Encoded Metabolic Modulation of the Tumor Microenvironment

  • Ashley Menk on Friday @ 6:15pm - Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma (also poster O11)

  • McLane (Mac) Watson on Saturday @5:51pm - Lactic acid metabolically supports the high suppressive function of tumor infiltrating regulatory T cells (also poster O13)

Two additional lab members are presenting during the poster sessions:

  • Dayana Rivadeneira - Fueling antitumor immunity using oncolytic viruses encoding metabolic modulators - P616

  • Yiyang “Steve” Wang - Metabolic reprogramming augments CAR T cell function - P208

And congrats to Dayana Rivadeneira, Nicole Scharping, and Mac Watson for winning Young Investigator Awards!

Come check us out to learn about our latest research in T cell metabolism and immunotherapy in the tumor microenvironment!

Summertime News from the Delgoffe Lab

Happy Summer from the Delgoffe Lab! Here are some highlights from what we've been up to the last few months:

New Funding

  • US Army/Department of Defense Translational Team Science Grant (CA170483 -  PIs Delgoffe, Najjar) - Metabolic Remodeling of the Tumor Microenvironment to Improve the Efficacy of Immunotherapy
  • NIH/NIAID R21AI135367 (PI: Delgoffe) - Illuminating metabolic pathways enabled by early T cell activation
  • NIH/NCI P50CA097190 (Project Leader: Delgoffe) - SPORE in Head and Neck Cancer Project 1: Evaluating and overcoming tumor hypoxia as a metabolic barrier to immunotherapy

And graduate Student Ronal Peralta was awarded funding from the University of Pittsburgh's Autoimmunity and Immunopathology Training Program T32.

 

New students

MSTP student Paolo Vignali and Konstantinos Lontos have officially joined our lab. Welcome!

 

Featured highlight from the lab

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PittMed magazine's Feast to Famine: Denying tumors what they need 

 

And finally, we're enjoying the sunshine!

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Updates from the Delgoffe Lab - Spring '18

Spring is here, bringing many new and exciting changes in the Delgoffe lab! We are happy to announce new funding, presentations at conferences, and new personnel to our lab! 

New funding in the Delgoffe Lab

  • Graduate Student Mac Watson was awarded funding from the University of Pittsburgh's Cancer Immunology Training Program T32.

National/International Presentations

  • Greg Delgoffe presented our lab's work on cancer immunometabolism at the Seventh Annual Tsinghua University-University of Pittsburgh Joint Symposium in Beijing, China.
  • Post doctoral fellow Dayana Rivadeneira presented her work on oncolytic viruses at the Immuno-Oncology Young Investigators’ Forum (IOYIF) in Huston, Texas.
  • Graduate student Nicole Scharping presented her work on the metabolic requirements for effective immunotherapy at the Ammerican Association for Cancer Research (AACR) Annual meeting in Chicago, Illinois.

New personnel

Medical fellow Yiyang "Steve" Wang, technician Nathaniel Flick, and graduate students Kristin DePeaux and Ronal Peralta have all joined the Delgoffe lab. Welcome all!

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Three new publications!

We're starting off 2018 strong with three new publications in the Delgoffe Lab!

Check out a new review by Dayana and Greg in Clinical Cancer Research: Antitumor T cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy.

It was a long time coming, but Menk & Scharping et al published in Cell Reports: Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

And the newest pub (which came out today!) by Menk et al in the Journal of Experimental Medicine: 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Go check out our new research, and congrats to all the lab members involved!

Recap - F99 Fellows meeting at the NCI

The 2017 F99 Fellows cohort

The 2017 F99 Fellows cohort

Fourth year graduate student Nicole Scharping, pictured above among other graduate students who received the F99 fellowship grant from the National Cancer Institute (NCI), recently attended a F99 Fellows meeting in Bethesda, MD. During this two day meeting, the fellows were able to meet and learn about one another's research, as well as learn about choosing post-doctoral mentors, careers in cancer research, and tour the NIH.